Pneumococcal serotype 3 otitis media, limited effect of polysaccharide conjugate immunisation and strain characteristics.

@article{Poolman2009PneumococcalS3,
  title={Pneumococcal serotype 3 otitis media, limited effect of polysaccharide conjugate immunisation and strain characteristics.},
  author={Jan T. Poolman and Pavla Kriz and Christiane M Feron and Emmanuel Di-Paolo and Isabelle Henckaerts and Agn{\`e}s Miseur and Dominique Wauters and Roman Prymula and Lode M Schuerman},
  journal={Vaccine},
  year={2009},
  volume={27 24},
  pages={3213-22}
}
BACKGROUND In contrast to the other vaccine serotypes, no protection could be demonstrated in the POET study against serotype 3 acute otitis media (AOM) following primary and booster vaccination with a multi-valent pneumococcal conjugate vaccine. METHODS AOM efficacy and immunogenicity data were reviewed. Pheno- and genotypic characteristics of different serotype 3 strains including efficacy study AOM isolates were evaluated. RESULTS Evaluation of vaccine efficacy before and after booster… CONTINUE READING

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