Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis.

Abstract

Summary The pneumococcal cell surface protein PavA is a virulence factor associated with adherence and invasion in vitro. In this study we show in vivo that PavA is necessary for Streptococcus pneumoniae D39 colonization of the murine upper respiratory tract in a long-term carriage model, with PavA-deficient pneumococci being quickly cleared from… (More)
DOI: 10.1111/j.2041-1014.2009.00561.x

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