Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis.

  title={Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis.},
  author={Johann Sebastian Braun and Jack E Sublett and Dorette Freyer and Tim J Mitchell and John L. Cleveland and Elaine I Tuomanen and Joerg R. Weber},
  journal={The Journal of clinical investigation},
  volume={109 1},
Pneumococcus is the most common and aggressive cause of bacterial meningitis and induces a novel apoptosis-inducing factor-dependent (AIF-dependent) form of brain cell apoptosis. Loss of production of two pneumococcal toxins, pneumolysin and H(2)O(2), eliminated mitochondrial damage and apoptosis. Purified pneumolysin or H(2)O(2) induced microglial and neuronal apoptosis in vitro. Both toxins induced increases of intracellular Ca(2+) and triggered the release of AIF from mitochondria. Chelating… CONTINUE READING


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