Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis.

@article{Manco2006PneumococcalNA,
  title={Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis.},
  author={Sonia Manco and Fidelma Hernon and Hasan Yesilkaya and James C. Paton and Peter W. Andrew and Aras Kadioglu},
  journal={Infection and immunity},
  year={2006},
  volume={74 7},
  pages={
          4014-20
        }
}
We examined the role of the neuraminidases NanA and NanB in colonization and infection in the upper and lower respiratory tract by Streptococcus pneumoniae, as well as the role of these neuraminidases in the onset and development of septicemia following both intranasal and intravenous infection. We demonstrated for the first time using outbred MF1 mouse models of infection that both NanA and NanB were essential for the successful colonization and infection of the upper and lower respiratory… CONTINUE READING

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