Pneumococcal Genetic Transformation During Colonization and Biofilm Formation

  title={Pneumococcal Genetic Transformation During Colonization and Biofilm Formation},
  author={A. H{\aa}kansson and L. Marks and Hazeline Roche-Hakansson},
Transformation of genetic material between bacteria was first observed in the 1920s using Streptococcus pneumoniae as a model organism. Since then, our understanding of the mechanisms involved in competence induction, DNA uptake, homologous recombination, and the regulation of these processes have been greatly improved, mainly using in vitro model systems. However, epidemiologic evidence suggests that genetic exchange occurs primarily during pneumococcal nasopharyngeal carriage that occurs in… CONTINUE READING
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