Pneumococcal Behavior and Host Responses during Bronchopneumonia Are Affected Differently by the Cytolytic and Complement-Activating Activities of Pneumolysin

@inproceedings{Jounblat2003PneumococcalBA,
  title={Pneumococcal Behavior and Host Responses during Bronchopneumonia Are Affected Differently by the Cytolytic and Complement-Activating Activities of Pneumolysin},
  author={Rania Jounblat and Aras Kadioglu and Timothy J. Mitchell and Peter W. Andrew},
  year={2003}
}
  • Rania Jounblat, Aras Kadioglu, +1 author Peter W. Andrew
  • Published 2003
  • Biology
  • Pneumolysin, a multifunctional toxin produced by all clinical isolates of Streptococcus pneumoniae, is strongly implicated in the pathogenesis of pneumococcal bronchopneumonia and septicemia. Using isogenic mutant strains, we examined the effect of deletion of the cytotoxic activity or complement-activating activity of pneumolysin on bacterial growth in lungs and blood, histological changes in infected lung tissue, and the pattern of inflammatory cell recruitment. Both of the activities of… CONTINUE READING

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