Pneumocandin biosynthesis: involvement of a trans-selective proline hydroxylase.

  title={Pneumocandin biosynthesis: involvement of a trans-selective proline hydroxylase.},
  author={Stefanie Houwaart and Loubna Youssar and Wolfgang H{\"u}ttel},
  journal={Chembiochem : a European journal of chemical biology},
  volume={15 16},
Echinocandins are cyclic nonribosomal hexapeptides based mostly on nonproteinogenic amino acids and displaying strong antifungal activity. Despite previous studies on their biosynthesis by fungi, the origin of three amino acids, trans-4- and trans-3-hydroxyproline, as well as trans-3-hydroxy-4-methylproline, is still unknown. Here we describe the identification, overexpression, and characterization of GloF, the first eukaryotic α-ketoglutarate/Fe(II) -dependent proline hydroxylase from the… CONTINUE READING
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