Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.

@article{Deb2011PnckIL,
  title={Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.},
  author={Tushar B. Deb and Annie Hong Zuo and Youhong Wang and Robert J. Barndt and Amrita K. Cheema and Surojeet Sengupta and Christine M. Coticchia and M. L. Johnson},
  journal={American journal of physiology. Cell physiology},
  year={2011},
  volume={300 5},
  pages={C1139-54}
}
We have recently described a novel role for pregnancy-upregulated non-ubiquitous calmodulin kinase (Pnck) in the induction of ligand-independent epidermal growth factor receptor (EGFR) degradation (Deb TB, Coticchia CM, Barndt R, Zuo H, Dickson RB, and Johnson MD. Am J Physiol Cell Physiol 295: C365-C377, 2008). In the current communication, we explore the probable mechanism by which Pnck induces ligand-independent EGFR degradation. Pnck-induced EGFR degradation is calcium/calmodulin… CONTINUE READING

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