PmrD is required for modifications to escherichia coli endotoxin that promote antimicrobial resistance.

@article{Rubin2015PmrDIR,
  title={PmrD is required for modifications to escherichia coli endotoxin that promote antimicrobial resistance.},
  author={Erica J. Rubin and Carmen M Herrera and Alexander A. Crofts and M. Stephen Trent},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 4},
  pages={2051-61}
}
In Salmonella enterica, PmrD is a connector protein that links the two-component systems PhoP-PhoQ and PmrA-PmrB. While Escherichia coli encodes a PmrD homolog, it is thought to be incapable of connecting PhoPQ and PmrAB in this organism due to functional divergence from the S. enterica protein. However, our laboratory previously observed that low concentrations of Mg(2+), a PhoPQ-activating signal, leads to the induction of PmrAB-dependent lipid A modifications in wild-type E. coli (C. M… CONTINUE READING

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