Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1

  title={Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1},
  author={Robin M Hobbs and Marco Seandel and Ilaria Falciatori and Shahin Rafii and Pier Paolo Pandolfi},
Hyperactivity of mTORC1, a key mediator of cell growth, leads to stem cell depletion, although the underlying mechanisms are poorly defined. Using spermatogonial progenitor cells (SPCs) as a model system, we show that mTORC1 impairs stem cell maintenance by a negative feedback from mTORC1 to receptors required to transduce niche-derived signals. We find that SPCs lacking Plzf, a transcription factor essential for SPC maintenance, have enhanced mTORC1 activity. Aberrant mTORC1 activation in Plzf… CONTINUE READING