Plutonium--health implications for man. What we have learned about plutonium from human data.

@article{Voelz1975PlutoniumhealthIF,
  title={Plutonium--health implications for man. What we have learned about plutonium from human data.},
  author={George L. Voelz},
  journal={Health physics},
  year={1975},
  volume={29 4},
  pages={
          551-61
        }
}
  • G. Voelz
  • Published 1 October 1975
  • Medicine
  • Health physics
Human data on plutonium deposition, internal distribution, and excretion have been obtained by observations after accidental occupational exposures, long- term follow-up studies on plutonium workers, and autopsy tissue analyses. No significant harmful effects have been noted in humans, although a small foreign- body type nodule around dermal implantations of plutonium has been described in eight persons. Methods used to estimate body burdens by urinary excretion values appear to be conservative… 

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The Biokinetics of Plutonium-239 and Americium-241 in the Rat After Subcutaneous Deposition of Contaminated Particles from the Former Nuclear Weapons Site at Maralinga: Implications for Human Exposure

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Experimental studies of the translocation of plutonium from simulated wound sites in the rat.

  • J. HarrisonA. DavidJ. Stather
  • Environmental Science
    International journal of radiation biology and related studies in physics, chemistry, and medicine
  • 1978
Wound contamination with plutonium was simulated in rats by injection into either muscle or subcutaneous tissue. The distribution after the injection of plutonium nitrate indicated that: (i)

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Beagle dogs were given subcutaneous implants of plutonium in their forepaws to mimic hand wounds received by workers accidentally contaminated with plutonium, and radionanalyses showed that the alpha activity was largely sequestered by scar tissue that replaced lymphoid parenchyma in the plutonium-oxide-injected dogs.

Dosimetry of 239Pu in dogs that inhaled monodisperse aerosols of 239PuO2.

The dosimetry results suggest that the lung and lymph nodes associated with lymphatic drainage of the respiratory tract are the principal sites of alpha irradiation in dogs that received single inhalation exposures to monodisperse aerosols of 239PuO2.

Biokinetics of inhaled 239PuO2 in the beagle dog: effect of aerosol particle size.

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Problems in radiological protection involving α-emitters in bone

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References

SHOWING 1-10 OF 10 REFERENCES

National Cancer Institute Monograph 33

  • 1971

A r c h

  • 1929

Proceedings of the Third Congress of the International Radiation Protection Association

  • Radiological Health and Safe9 In Mining and Milting of Nuclear Materials
  • 1964

Battelle Northwest Laboratory Document BNWL-SA-4077

  • 1971

Radiobiology of Plutonium (Edited by STOVER B

  • J. and JEE W. S. S.),
  • 1972

Radionuclide Carcinogenesis

  • AEC Symposium Series
  • 1973

Diagnosis and LA-5633-PR, 27. Treatment of Deposited Radionuclides

  • Excerpta Medica Foundation)
  • 1968

Natural Resources Defense Council (NRDC) report, Washington, D.C

  • 1974

Radiobiology of Plutonium (Edited by STOVER

  • 1972