Pluronic p85 block copolymer enhances opioid peptide analgesia.

@article{Witt2002PluronicPB,
  title={Pluronic p85 block copolymer enhances opioid peptide analgesia.},
  author={Ken A. Witt and Jason Delwyn Huber and Richard D. Egleton and Thomas P Davis},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={303 2},
  pages={760-7}
}
Peptide-based drug development is a rapidly growing field within pharmaceutical research. Nevertheless, peptides have found limited clinical use due to several physiological and pathological factors. Pluronic block copolymers represent a growing technology with the potential to enhance efficacy of peptide therapeutics. This investigation assesses Pluronic P85 (P85) and its potential to enhance opioid peptide analgesia. Two opioid peptides, [D-Pen(2),D-Pen(5)]-enkephalin (DPDPE) and biphalin… CONTINUE READING

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