Pluronic copolymer encapsulated SCR7 as a potential anticancer agent.

Abstract

Nonhomologous end joining (NHEJ) of DNA double strand breaks (DSBs) inside cells can be selectively inhibited by 5,6-bis-(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) which possesses anticancer properties. The hydrophobicity of SCR7 decreases its bioavailability which is a major setback in the utilization of this compound as a therapeutic agent. In order to circumvent the drawback of SCR7, we prepared a polymer encapsulated form of SCR7. The physical interaction of SCR7 and Pluronic® copolymer is evident from different analytical techniques. The in vitro cytotoxicity of the drug formulations is established using the MTT assay.

DOI: 10.1039/c4fd00176a

Cite this paper

@article{John2015PluronicCE, title={Pluronic copolymer encapsulated SCR7 as a potential anticancer agent.}, author={Franklin John and Jinu George and Mrinal Ranjan Srivastava and Puthusserickal Abdulrahiman Hassan and Vinod K Aswal and Subhas Somalingappa Karki and Sathees C. Raghavan}, journal={Faraday discussions}, year={2015}, volume={177}, pages={155-61} }