Pluronic block copolymers: novel functional molecules for gene therapy.

  title={Pluronic block copolymers: novel functional molecules for gene therapy.},
  author={Alexander V Kabanov and Pierre Lemieux and Sergey L. Vinogradov and Valery Alakhov},
  journal={Advanced drug delivery reviews},
  volume={54 2},
Pluronic block copolymers are recognized pharmaceutical excipients listed in the US and British Pharmacopoeia. They have been used extensively in a variety of pharmaceutical formulations including delivery of low molecular mass drugs and polypeptides. This review describes novel applications of Pluronic block copolymers in gene therapy. In particular, these molecules can modify the biological response during gene therapy in the skeletal muscle, resulting in an enhancement of the transgene… CONTINUE READING