Pluronic F127 polymeric micelles for co-delivery of paclitaxel and lapatinib against metastatic breast cancer: preparation, optimization and in vitro evaluation.

Abstract

Abstract The aim of this study was to develop and characterize the paclitaxel (PTX)-lapatinib (LPT) loaded micelles for simultaneous delivery against metastatic breast cancer. Efflux pump-mediated drug resistance influences the efficacy of chemotherapeutic regimens. However, in the newly developed delivery system, LPT was selected to act as chemosensetizer… (More)

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Cite this paper

@article{Kelishady2014PluronicFP, title={Pluronic F127 polymeric micelles for co-delivery of paclitaxel and lapatinib against metastatic breast cancer: preparation, optimization and in vitro evaluation.}, author={Pooya Dehghan Kelishady and Ebrahim Saadat and Fatemeh Ravar and Hamid Reza Akbari and Farid Abedin Dorkoosh}, journal={Pharmaceutical development and technology}, year={2014}, pages={1-9} }