Pluronic F127 enhances the effect as an adjuvant of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxin.

@article{Kang2007PluronicFE,
  title={Pluronic F127 enhances the effect as an adjuvant of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxin.},
  author={Mi Lan Kang and Hu-Lin Jiang and Sang Gyun Kang and Ding Ding Guo and Deog Yong Lee and Chong-su Cho and Han Sang Yoo},
  journal={Vaccine},
  year={2007},
  volume={25 23},
  pages={
          4602-10
        }
}
We have studied a vaccine delivery system in vitro and in vivo based on chitosan microspheres (CMs) prepared in the presence of selected immunomodulators, Pluronic block copolymer F127 (F127). The Bordetella bronchiseptica multiple antigens containing dermonecrotoxin (BBD), a virulent factor leading to atrophic rhinitis (AR) in swine was loaded in CMs/F127 or CMs alone. The microspheres, prepared using an ionic gelation process with tripolyphosphate, demonstrated release profiles that showed a… CONTINUE READING

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