Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application

Abstract

Human pluripotent stem cells [PSCs; including human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)] can infinitely proliferate in vitro and are easily accessible for gene manipulation. Megakaryocytes (MKs) and platelets can be created from human ESCs and iPSCs in vitro and represent a potential source of blood cells for transfusion… (More)
DOI: 10.1007/s00018-012-0995-4

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