Pluripotent neural crest stem cells in the adult hair follicle

@article{SieberBlum2004PluripotentNC,
  title={Pluripotent neural crest stem cells in the adult hair follicle},
  author={Maya Sieber-Blum and Milo{\vs} Grim and Y F Hu and Viktor Szeder},
  journal={Developmental Dynamics},
  year={2004},
  volume={231}
}
We report the presence of pluripotent neural crest stem cells in the adult mammalian hair follicle. [] Key Result Bulge explants from adult mouse whisker follicles yield migratory neural crest cells, which in clonal culture form colonies consisting of over a thousand cells. Clones contain neurons, smooth muscle cells, rare Schwann cells and melanocytes, demonstrating pluripotency of the clone-forming cell.
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376 Citations
Highly Influential Citations
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376 Citations

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Isolation and culture of neural crest stem cells from human hair follicles.
TLDR
The hair follicle/skin derived NCSCs have already shown promising results for regenerative therapy in preclinical models and exhibit clonal multipotency that can give rise to myogenic, melanocytic, and neuronal cell lineages after in vitro clonal single cell culture.
Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves.
  • Y. Amoh, Lingna Li, +4 authors R. Hoffman
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
TLDR
The results suggest that hair follicle stem cells provide an important, accessible, autologous source of adult stem cells for regenerative medicine.
Multipotent nestin‐expressing hair follicle stem cells
TLDR
Hair follicle stem cells are pluripotent and provide an effective, accessible, autologous source of stem cells for treatment of peripheral nerve injury and appear to be a paradigm for adult stem cells.
Neural Potential of a Stem Cell Population in the Hair Follicle
TLDR
The results show that nestin-expressing cells in the bulge of the hair follicle have stem cell-like properties, are multipotent, and can effectively generate cells of neural lineage in vitro and in vivo.
Isolation and characterization of neural crest stem cells from adult human hair follicles.
TLDR
Results strongly support the NCSC identity and multipotency of isolated human cells and could thus be used in regenerative medicine, especially because of the easy accessibility of donor tissue.
Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells
  • E. Sviderskaya, D. Easty, +6 authors D. Bennett
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2009
TLDR
Novel pluripotent neural crest‐like stem cells from neonatal mouse epidermis are described, with different potencies, isolated as 3 independent immortal lines, to generate comparative gene expression data for the stem cells, melanocytes, and melanoblasts that sufficiently explain the lack of pigment in melanoblast and provide a rationale for some genes expressed apparently ectopically in melanomas.
Stem cells with neural crest characteristics derived from the bulge region of cultured human hair follicles.
TLDR
It is demonstrated that it can isolate stem cells (SCs) with neural crest characteristics from the bulge area of cultured human hair follicles (HFs) and these SCs show differentiation potential toward mesenchymal lineages, and they can be differentiated into adipocyte, chondrocyte, and osteocyte lineages.
Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function
TLDR
It is suggested that hair follicle stem cells can promote the recovery of spinal cord injury and provide an effective accessible, autologous source of stem cells for the promising treatment of peripheral nerve and spinal Cord injury.
Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles
TLDR
The results suggest that NC-derived hair follicle cells possess a capacity for osteoblastic differentiation and may be useful for developing new bone regenerative medicine therapies.
Isolation and differentiation properties of neural crest stem cells
TLDR
In vivo and in vitro studies of individual cells, which led to the discovery and characterization of neural crest progenitors endowed with multipotency and stem cell properties, are reviewed.
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