Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

@article{Hou2013PluripotentSC,
  title={Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds},
  author={Pingping Hou and Yanqin Li and Xu Zhang and Chun Liu and Jingyang Guan and Honggang Li and Ting Zhao and Junqing Ye and Weifeng Yang and Kang Liu and Jian Ge and Jun Xu and Qiang Zhang and Yang Zhao and Hongkui Deng},
  journal={Science},
  year={2013},
  volume={341},
  pages={651 - 654}
}
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource, with potential for studying disease and use in regenerative medicine. [] Key Result The chemically induced pluripotent stem cells resemble embryonic stem cells in terms of their gene expression profiles, epigenetic status, and potential for differentiation and germline transmission. By using small molecules, exogenous "master genes" are dispensable for cell fate reprogramming. This chemical reprogramming strategy…

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