Pluripotency of mesenchymal stem cells derived from adult marrow

@article{Jiang2002PluripotencyOM,
  title={Pluripotency of mesenchymal stem cells derived from adult marrow},
  author={Yue-hua Jiang and B. Jahagirdar and R. Reinhardt and R. Schwartz and C. Keene and X. Ortiz-Gonzalez and M. Reyes and T. Lenvik and T. Lund and M. Blackstad and Jingbo Du and S. Aldrich and A. Lisberg and W. Low and D. Largaespada and C. Verfaillie},
  journal={Nature},
  year={2002},
  volume={418},
  pages={41-49}
}
We report here that cells co-purifying with mesenchymal stem cells—termed here multipotent adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro. When injected into an early blastocyst, single MAPCs contribute to most, if not all, somatic cell types. On transplantation into a non-irradiated host, MAPCs engraft and differentiate to the haematopoietic… Expand

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