Pluripotency of mesenchymal stem cells derived from adult marrow

@article{Jiang2002PluripotencyOM,
  title={Pluripotency of mesenchymal stem cells derived from adult marrow},
  author={Yue-hua Jiang and Balkrishna N. Jahagirdar and R. Reinhardt and Robert E. Schwartz and C. Dirk Keene and Xilma R. Ortiz-Gonz{\'a}lez and Morayma Reyes and Todd R. Lenvik and Troy C Lund and Mark Blackstad and Jingbo Du and Sara Aldrich and Aaron Lisberg and Walter C. Low and David A. Largaespada and Catherine M. Verfaillie},
  journal={Nature},
  year={2002},
  volume={418},
  pages={41-49}
}
We report here that cells co-purifying with mesenchymal stem cells—termed here multipotent adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro. When injected into an early blastocyst, single MAPCs contribute to most, if not all, somatic cell types. On transplantation into a non-irradiated host, MAPCs engraft and differentiate to the haematopoietic… 

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