Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

  title={Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues},
  author={J. Hanna and K. Saha and R. Jaenisch},
  • J. Hanna, K. Saha, R. Jaenisch
  • Published 2010
  • Biology, Medicine
  • Cell
  • Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripotency can interconvert through the modulation of both cell-intrinsic and exogenous factors. To fully realize the potential of in vitro reprogrammed cells, we need to understand the molecular and… CONTINUE READING
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