Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement.

@article{Vellinga2008PluriformityOI,
  title={Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement.},
  author={Machteld M. Vellinga and Raoul D Oude Engberink and Alexandra Seewann and Petra J. W. Pouwels and Mike P. Wattjes and Susanne M. A. van der Pol and Christiane Pering and Chris H. Polman and Helga Eveline de Vries and J. J. G. Geurts and Frederik Barkhof},
  journal={Brain : a journal of neurology},
  year={2008},
  volume={131 Pt 3},
  pages={800-7}
}
Gadolinium-DTPA (Gd-DTPA) is routinely used as a marker for inflammation in MRI to visualize breakdown of the blood-brain barrier (BBB) in multiple sclerosis. Recent data suggest that ultra-small superparamagnetic particles of iron oxide (USPIO) can be used to visualize cellular infiltration, another aspect of inflammation. This project aimed to compare the novel USPIO particle SHU555C to the longitudinal pattern of Gd-DTPA enhancement in multiple sclerosis. Nineteen relapsing-remitting… CONTINUE READING