Plurality of anxiety and depression alteration mechanism by oleanolic acid.

  title={Plurality of anxiety and depression alteration mechanism by oleanolic acid.},
  author={James Oluwagbamigbe Fajemiroye and Pablinny Moreira Galdino and Iziara Ferreira Florentino and F{\'a}bio Fagundes da Rocha and Paulo C{\'e}sar Ghedini and Prabhakar Reddy Polepally and Jordan Kordian Zjawiony and Elson A Costa},
  journal={Journal of psychopharmacology},
  volume={28 10},
Our study sought to evaluate the anxiolytic and antidepressant activities of oleanolic acid as well as the neural mechanisms involved. Animal models such as barbiturate sleep-induction, light-dark box, elevated plus maze, forced swimming test, tail suspension test and open field test were conducted. Male Albino Swiss mice were treated orally with vehicle 10 mL/kg, fluoxetine 20 mg/kg, imipramine 15 mg/kg, diazepam 1 mg/kg or oleanolic acid 5-40 mg/kg. Pretreatment (intraperitoneal) of animals… CONTINUE READING
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