Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells.

@article{Wang2008PlumbaginIC,
  title={Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells.},
  author={Clay C C Wang and Yi-Ming Chiang and Shu-Chiao Sung and Ya-Ling Hsu and Jiunn-Kae Chang and Po-Lin Kuo},
  journal={Cancer letters},
  year={2008},
  volume={259 1},
  pages={
          82-98
        }
}
This study is the first to investigate the anticancer effect of plumbagin in human melanoma A375.S2 cells. Plumbagin exhibited effective cell growth inhibition by inducing cancer cells to undergo S-G2/M phase arrest and apoptosis. Further investigation revealed that plumbagin's inhibition of cell growth was also evident in a nude mice model. Blockade of cell cycle was associated with increased levels of p21, and reduced amounts of cyclin B1, cyclin A, Cdc2, and Cdc25C. Plumbagin also enhanced… CONTINUE READING

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