Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH2-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo

@article{Hsu2006PlumbaginI,
  title={Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH2-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo},
  author={Ya-Ling Hsu and Chien-Yu Cho and Po-Lin Kuo and Yu-Ting Huang and Chun-ching Lin},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={318},
  pages={484 - 494}
}
  • Y. Hsu, C. Cho, Chun-ching Lin
  • Published 1 August 2006
  • Biology, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
This study first investigates the anticancer effect of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) in human nonsmall cell lung cancer cells, A549. Plumbagin has exhibited effective cell growth inhibition by inducing cancer cells to undergo G2/M phase arrest and apoptosis. Blockade of cell cycle was associated with increased levels of p21 and reduced amounts of cyclinB1, Cdc2, and Cdc25C. Plumbagin treatment also enhanced the levels of inactivated phosphorylated Cdc2 and Cdc25C. Blockade… 

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