Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia.

@article{Son2010PlumbaginAN,
  title={Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia.},
  author={Tae Gen Son and Simonetta Camandola and Thiruma Valavan Arumugam and Roy Gail Cutler and Richard S. Telljohann and Mohamed R. Mughal and Tyson A. Moore and Weiming Luo and Qian-sheng Yu and D. Aaron Johnson and Jeffrey A. Johnson and Debomoy K. Lahiri and Mark P. Mattson},
  journal={Journal of neurochemistry},
  year={2010},
  volume={112 5},
  pages={
          1316-26
        }
}
Many phytochemicals function as noxious agents that protect plants against insects and other damaging organisms. However, at subtoxic doses, the same phytochemicals may activate adaptive cellular stress response pathways that can protect cells against a variety of adverse conditions. We screened a panel of botanical pesticides using cultured human and rodent neuronal cell models, and identified plumbagin as a novel potent activator of the nuclear factor E2-related factor 2 (Nrf2)/antioxidant… CONTINUE READING
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