Ploidy influences cellular responses to gross chromosomal rearrangements in saccharomyces cerevisiae

Abstract

Gross chromosomal rearrangements (GCRs) such as aneuploidy are key factors in genome evolution as well as being common features of human cancer. Their role in tumour initiation and progression has not yet been completely elucidated and the effects of additional chromosomes in cancer cells are still unknown. Most previous studies in which Saccharomyces… (More)
DOI: 10.1186/1471-2164-12-331

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