Ploidy distribution in experimental liver carcinogenesis in mice.

  title={Ploidy distribution in experimental liver carcinogenesis in mice.},
  author={H{\aa}vard E. Danielsen and Harald Steen and Tore Lindmo and Albrecht Reith},
  volume={9 1},
There have been several reports on the distribution of DNA in premalignant and malignant liver cells after carcinogen treatment in rodents. The most striking result so far is that ploidy distributions seems to depend more on experimental protocols and less on carcinogenesis per se. The present study demonstrates that an evaluation by means of flow cytometry and stereological image analysis yields results showing similar ploidy distributions throughout the known sequence of tissue changes seen… CONTINUE READING

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