Ploidy Controls the Success of Mutators and Nature of Mutations during Budding Yeast Evolution

@article{Thompson2006PloidyCT,
  title={Ploidy Controls the Success of Mutators and Nature of Mutations during Budding Yeast Evolution},
  author={Dawn A Thompson and Michael M Desai and Andrew W. Murray},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={1581-1590}
}
BACKGROUND We used the budding yeast Saccharomyces cerevisiae to ask how elevated mutation rates affect the evolution of asexual eukaryotic populations. Mismatch repair defective and nonmutator strains were competed during adaptation to four laboratory environments (rich medium, low glucose, high salt, and a nonfermentable carbon source). RESULTS In diploids, mutators have an advantage over nonmutators in all conditions, and mutators that win competitions are on average fitter than nonmutator… CONTINUE READING

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