Ploidy, as detected by fluorescence in situ hybridization, defines different subgroups in multiple myeloma

@article{Wuillme2004PloidyAD,
  title={Ploidy, as detected by fluorescence in situ hybridization, defines different subgroups in multiple myeloma},
  author={Soraya Wuill{\`e}me and Nelly Robillard and Laurence Lod{\'e} and Florence Magrangeas and Helen Beris and J-L Harousseau and J Proffitt and S Minvielle and Herv{\'e} Avet-Loiseau},
  journal={Leukemia},
  year={2004},
  volume={19},
  pages={275-278}
}
Ploidy appears as an important parameter in both the biology and the clinical evolution of multiple myeloma. However, its evaluation requires either a successful karyotyping (obtained in 30% of the patients) or a DNA index calculation by flow cytometry (not routinely performed in myeloma). We validated a novel method based on interphase fluorescence in situ hybridization that can be utilitized to analyze almost all the patients. The method was very specific and sensitive for the detection of… CONTINUE READING

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