Plk4 trans-autophosphorylation regulates centriole number by controlling βTrCP-mediated degradation

  title={Plk4 trans-autophosphorylation regulates centriole number by controlling $\beta$TrCP-mediated degradation},
  author={Gernot Guderian and Jens Westendorf and Andreas Uldschmid and Erich A. Nigg},
  journal={Journal of Cell Science},
  pages={2163 - 2169}
Centrioles are the main constituents of the mammalian centrosome and act as basal bodies for ciliogenesis. Centrosomes organize the cytoplasmic microtubule network during interphase and the mitotic spindle during mitosis, and aberrations in centrosome number have been implicated in chromosomal instability and tumor formation. The centriolar protein Polo-like kinase 4 (Plk4) is a key regulator of centriole biogenesis and is crucial for maintaining constant centriole number, but the mechanisms… 

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