Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

@inproceedings{Dzhindzhev2014Plk4PA,
  title={Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation},
  author={Nikola S. Dzhindzhev and George Tzolovsky and Zoltan Lipinszki and Sandra Schneider and Ramona Lattao and Jingyan Fu and Janusz Debski and Michał Dadlez and David M Glover},
  booktitle={Current Biology},
  year={2014}
}
Centrioles are 9-fold symmetrical structures at the core of centrosomes and base of cilia whose dysfunction has been linked to a wide range of inherited diseases and cancer. Their duplication is regulated by a protein kinase of conserved structure, the C. elegans ZYG-1 or its Polo-like kinase 4 (Plk4) counterpart in other organisms. Although Plk4's centriolar partners and mechanisms that regulate its stability are known, its crucial substrates for centriole duplication have never been… CONTINUE READING
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