Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.

@article{Xie2001Plk3FL,
  title={Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.},
  author={Suqing Xie and Hong Wu and Qin Wang and John P. Cogswell and Intisar Husain and Coco Conn and Peter Stambrook and Meena Jhanwar-Uniyal and Wei Dai},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 46},
  pages={43305-12}
}
Polo-like kinase 3 (Plk3, previously termed Prk) contributes to regulation of M phase of the cell cycle (Ouyang, B., Pan, H., Lu, L., Li, J., Stambrook, P., Li, B., and Dai, W. (1997) J. Biol. Chem. 272, 28646-28651). Plk3 physically interacts with Cdc25C and phosphorylates this protein phosphatase predominantly on serine 216 (Ouyang, B., Li, W., Pan, H., Meadows, J., Hoffmann, I., and Dai, W. (1999) Oncogene 18, 6029-6036), suggesting that the role of Plk3 in mitosis is mediated, at least in… CONTINUE READING