Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis

@article{Crcer2017Plk1RC,
  title={Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis},
  author={Guillermo de C{\'a}rcer and Paulina Wachowicz and Sara Mart{\'i}nez-Mart{\'i}nez and Jorge Oller and Nerea M{\'e}ndez-Barbero and Beatriz Escobar and Alejandra Gonz{\'a}lez-Loyola and Tohru Takaki and Aicha El Bakkali and Juan Antonio C{\'a}mara and Luis Jes{\'u}s Jim{\'e}nez-Borreguero and Xos{\'e} R Bustelo and Marta Ca{\~n}amero and Francisca Mulero and Mar{\'i}a de los {\'A}ngeles Sevilla and Mar{\'i}a Jos{\'e} Montero and Juan Miguel Redondo and Marcos Malumbres},
  journal={Nature Medicine},
  year={2017},
  volume={23},
  pages={964-974}
}
Polo-like kinase 1 (PLK1), an essential regulator of cell division, is currently undergoing clinical evaluation as a target for cancer therapy. We report an unexpected function of Plk1 in sustaining cardiovascular homeostasis. Plk1 haploinsufficiency in mice did not induce obvious cell proliferation defects but did result in arterial structural alterations, which frequently led to aortic rupture and death. Specific ablation of Plk1 in vascular smooth muscle cells (VSMCs) led to reduced arterial… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 45 times over the past 90 days. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 70 references

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice

  • M Trakala
  • Blood 126,
  • 2015

Similar Papers

Loading similar papers…