Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells.

@article{Soung2009Plk1dependentA,
  title={Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells.},
  author={Nak-Kyun Soung and Jung-Eun · Lee Park and Li-Rong Yu and Kyung ho Lee and Jung-min Lee and Jeong Kyu Bang and Timothy D. Veenstra and Kunsoo Rhee and Kyung S Lee},
  journal={Developmental cell},
  year={2009},
  volume={16 4},
  pages={
          539-50
        }
}
Outer dense fiber 2 (ODF2) was initially identified as a major component of the sperm tail cytoskeleton, and was later suggested to be localized to somatic centrosomes and required for the formation of primary cilia. Here we show that a splice variant of hODF2 called hCenexin1, but not hODF2 itself, efficiently localizes to somatic centrosomes via a variant-specific C-terminal extension and recruits Plk1 through a Cdc2-dependent phospho-S796 motif within the extension. This interaction and Plk1… CONTINUE READING
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