Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

@inproceedings{Burkard2009Plk1SA,
  title={Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells},
  author={Mark E Burkard and John Maciejowski and Ver{\'o}nica Rodr{\'i}guez-Bravo and Michael Repka and Drew M. Lowery and Karl R. Clauser and Chao Zhang and Kevan M. Shokat and Steven A. Carr and Michael B. Yaffe and Prasad V. Jallepalli},
  booktitle={PLoS biology},
  year={2009}
}
Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues provided by anaphase spindle microtubules (MTs), but how such cues are generated remains unclear. Using chemical genetics to achieve both temporal and spatial control, we show that the self-organized delivery of Polo-like kinase 1 (Plk1) to the… CONTINUE READING
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