Plk1-Mediated Phosphorylation of TSC1 Enhances the Efficacy of Rapamycin.

@article{Li2018Plk1MediatedPO,
  title={Plk1-Mediated Phosphorylation of TSC1 Enhances the Efficacy of Rapamycin.},
  author={Zhiguo Li and Yifan Kong and Longzhen Song and Qian Luo and Jinghui Liu and Chen Shao and Xianzeng Hou and X John{\'e} Liu},
  journal={Cancer research},
  year={2018},
  volume={78 11},
  pages={
          2864-2875
        }
}
The AKT/TSC/mTOR axis is an important pathway controlling cell growth, survival, and proliferation in response to extracellular cues. Recently, it was reported that AKT activity fluctuates across the cell cycle. However, it remains unclear whether downstream targets of AKT are also regulated by the cell cycle. Here, we report that mTORC1 activity inversely… CONTINUE READING