Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

  title={Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A},
  author={Kris M. White and Romel Rosales and Soner Yildiz and Thomas Kehrer and Lisa Miorin and Elena Moreno and Sonia Jangra and Melissa B. Uccellini and Raveen Rathnasinghe and Lynda Coughlan and Carles Mart{\'i}nez-Romero and Jyoti Batra and Ajda Rojc and Mehdi Bouhaddou and Jacqueline M. Fabius and Kirsten Obernier and Marion Dejosez and Mar{\'i}a Jos{\'e} Guill{\'e}n and Alejandro Losada and Pablo M. Avil{\'e}s and Michael Schotsaert and Thomas P. Zwaka and Marco Vignuzzi and Kevan M. Shokat and Nevan J. Krogan and Adolfo Garc{\'i}a-Sastre},
  journal={Science (New York, N.y.)},
  pages={926 - 931}
Hurting the virus by targeting the host Many host proteins play a role in the life cycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and some are required for viral replication and translation. There are efforts toward finding drugs that target viral proteins, but a complementary approach is to target these required host proteins. White et al. explored the antiviral activity of the cyclic depsipeptide drug plitidepsin, which targets the hosts cell's translational machinery… Expand
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