PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla.

@article{Choi2008PlexinD1GC,
  title={PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla.},
  author={Young Il Choi and Jonathan S Duke-Cohan and Wesam B Ahmed and Maris A Handley and Fanny Mann and Jonathan A. Epstein and Linda K. Clayton and Ellis L. Reinherz},
  journal={Immunity},
  year={2008},
  volume={29 6},
  pages={888-98}
}
Precise intrathymic cell migration is important for thymocyte maturation and organ architecture. The orchestration of thymocyte trafficking, however, is not well understood at a molecular level. Here, we described highly regulated plexinD1 expression on CD4+CD8+ double positive (DP) thymocytes. PlexinD1 expression was further affected by the engagement of T cell receptor complex. Activation of plexinD1 via the ligand, semaphorin 3E, repressed CCL25 chemokine signaling via its receptor CCR9 in… CONTINUE READING

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