PlexinA1 Autoinhibition by the Plexin Sema Domain

@article{Takahashi2001PlexinA1AB,
  title={PlexinA1 Autoinhibition by the Plexin Sema Domain},
  author={Toshitada Takahashi and Stephen M Strittmatter},
  journal={Neuron},
  year={2001},
  volume={29},
  pages={429-439}
}
Semaphorin 3A (Sema3A) binds to neuropilin-1 (NP1) and activates the transmembrane Plexin to transduce a repulsive axon guidance signal. Here, we show that Sema3 signals are transduced equally effectively by PlexinA1 or PlexinA2, but not by PlexinA3. Deletion analysis of the PlexinA1 ectodomain demonstrates that the sema domain prevents PlexinA1 activation in the basal state. Sema-deleted PlexinA1 is constitutively active, producing cell contraction, growth cone collapse, and inhibition of… CONTINUE READING
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