Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells

@inproceedings{Argast2009PlexinBI,
  title={Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells},
  author={Gretchen M. Argast and Carrie Hughes Croy and Kasey L. Couts and Zhiyong Zhang and Elizabeth S. Litman and Daniel C. Chan and Natalie G Ahn},
  booktitle={Oncogene},
  year={2009}
}
Human melanomas show oncogenic B-Raf mutations, which activate the B-Raf/MKK/ERK cascade. We screened microarrays to identify cellular targets of this pathway, and found that genes upregulated by B-Raf/MKK/ERK showed highest association with cell-cycle regulators, whereas genes downregulated were most highly associated with axon guidance genes, including plexin–semaphorin family members. Plexin B1 was strongly inhibited by mitogen-activated protein kinase signaling in melanoma cells and… CONTINUE READING

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