Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension.

@article{White2007PlexiformlikeLA,
  title={Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension.},
  author={R. J. White and D. Meoli and Robert F. Swarthout and D. Kallop and I. I. Galaria and Jennifer L Harvey and C. M. Miller and B. Blaxall and C. M. Hall and R. Pierce and C. Cool and M. Taubman},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 3},
  pages={
          L583-90
        }
}
Severe pulmonary arterial hypertension (PAH) occurs in idiopathic form and in association with diverse diseases. The pathological hallmarks are distal smooth muscle hypertrophy, obliteration of small pulmonary arteriole lumens, and disorganized cellular proliferation in plexiform lesions. In situ thrombosis is also observed. A detailed understanding of the disease progression has been hampered by the absence of an animal model bearing all the pathological features of human disease. To create a… Expand
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