Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex.

@article{Tomita2004PleurotolysinAN,
  title={Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex.},
  author={Toshio Tomita and Kayoko Noguchi and Hitomi Mimuro and Fumio Ukaji and Kiyoshi Ito and Noriko Sugawara-Tomita and Yohichi Hashimoto},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 26},
  pages={26975-82}
}
Self-assembling, pore-forming cytolysins are illustrative molecules for the study of the assembly and membrane insertion of transmembrane pores. Here we purified pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the basidiocarps of Pleurotus ostreatus and studied the pore-forming properties of the cytolysin. Pleurotolysin consisted… CONTINUE READING