Pleurocidin, a novel antimicrobial peptide, induces human mast cell activation through the FPRL1 receptor

@article{Pundir2014PleurocidinAN,
  title={Pleurocidin, a novel antimicrobial peptide, induces human mast cell activation through the FPRL1 receptor},
  author={Priyanka Pundir and Adriana Catalli and Cindy Leggiadro and Susan E. Douglas and Marianna Kulka},
  journal={Mucosal Immunology},
  year={2014},
  volume={7},
  pages={177-187}
}
Pleurocidins are a novel family of α-helical cationic antimicrobial peptides (CAPs) that are structurally and functionally similar to cathelicidins, one of the major CAP families. As cathelicidins stimulate mast cell chemotaxis and mediator release, we postulated that pleurocidins similarly activate mast cells. A screen of 20 pleurocidin peptides revealed… CONTINUE READING