Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis

@inproceedings{Weber2014PleuralIR,
  title={Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis},
  author={Georg F Weber and Benjamin G. Chousterman and Ingo Hilgendorf and Clinton S. Robbins and Igor M Theurl and Louisa M. S. Gerhardt and Yoshiko Iwamoto and T{\^a}m Dan Qu{\'a}ch and Muhammad Anjum Ali and John W. Chen and Thomas L. Rothstein and Matthias Nahrendorf and Ralph Weissleder and Filip K Swirski},
  booktitle={The Journal of experimental medicine},
  year={2014}
}
Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection, B1a B cells migrate from the pleural space to the lung parenchyma to secrete polyreactive emergency immunoglobulin M (IgM). The process requires innate response activator (IRA) B cells, a transitional B1a-derived inflammatory subset which… CONTINUE READING
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