Pleural fluid eosinophils suppress local IgE-mediated protein exudation in rats.

@article{BandeiraMelo1995PleuralFE,
  title={Pleural fluid eosinophils suppress local IgE-mediated protein exudation in rats.},
  author={Christianne Bandeira-Melo and Patr{\'i}cia Machado Rodrigues e Silva and Renato S B Cordeiro and Marco Aur{\'e}lio Martins},
  journal={Journal of leukocyte biology},
  year={1995},
  volume={58 4},
  pages={395-402}
}
Eosinophils are supposed to play a critical role in the pathology of several allergic diseases because after activation they can release toxic and proinflammatory agents. In this study we have investigated whether IgE-mediated rat pleurisy could be affected by an ongoing pleural eosinophilic inflammatory response. IgE-passively sensitized rats were challenged with an intrapleural (i.pl.) injection of allergen (dinitrophenylated bovine serum albumin, 1 microgram/cavity) and exudation assessed by… CONTINUE READING