Pleural-based mesothelioma in immune competent rats: a model to study adenoviral gene transfer.

@article{Kucharczuk1995PleuralbasedMI,
  title={Pleural-based mesothelioma in immune competent rats: a model to study adenoviral gene transfer.},
  author={John Charles Kucharczuk and A. A. Elshami and Han Bing Zhang and William Roy Smythe and Harry C. Hwang and James S Tomlinson and Kunjlata Manibhai Amin and Leslie Anne Litzky and Steven M. Albelda and Larry Robert Kaiser},
  journal={The Annals of thoracic surgery},
  year={1995},
  volume={60 3},
  pages={593-7; discussion 597-8}
}
BACKGROUND Despite multimodality approaches, pleural-based malignant mesothelioma remains a disease with a very poor prognosis. Novel therapeutic strategies such as gene therapy clearly are needed to improve the survival of patients with this neoplasm. To aid in the evaluation of new treatment strategies, animal models that closely mimic human disease are required. This article describes the establishment of a pleural-based model of malignant mesothelioma in immune-competent Fischer rats… CONTINUE READING