Plerixafor, a CXCR4 antagonist for the mobilization of hematopoietic stem cells.

Abstract

Stem cells harvested from peripheral blood are the most commonly used graft source in hematopoietic stem cell transplantation. While G-CSF is the most frequently used agent for stem cell mobilization, the use of G-CSF alone results in suboptimal stem cell yields in a significant proportion of patients undergoing autologous transplantation. Plerixafor… (More)
DOI: 10.1517/14712598.8.11.1797

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