Pleomorphism of the nuclear envelope in breast cancer: a new approach to an old problem

  title={Pleomorphism of the nuclear envelope in breast cancer: a new approach to an old problem},
  author={Gianni Bussolati and Caterina Marchi{\`o} and Laura Gaetano and Rosanna Lupo and Anna Sapino},
  booktitle={Journal of cellular and molecular medicine},
In routine practice, nuclear pleomorphism of tumours is assessed by haematoxylin staining of the membrane-bound heterochromatin. However, decoration of the nuclear envelope (NE) through the immunofluorescence staining of NE proteins such as lamin B and emerin can provide a more objective appreciation of the nuclear shape. In breast cancer, nuclear pleomorphism is one of the least reproducible parameters to score histological grade, thus we sought to use NE proteins to improve the… CONTINUE READING


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