Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

@inproceedings{Gale2016PleiotropyBN,
  title={Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank},
  author={Catharine R Gale and Saskia P Hagenaars and Gail Davies and W. David Hill and David Cherry McLachlan Liewald and Bryan Cullen and Brenda W. J. H. Penninx and Dorret I. Boomsma and Jonathan Pell and A. M. McIntosh and Dustin Smith and Ian J. Deary and Stephanie Harris},
  booktitle={Translational Psychiatry},
  year={2016}
}
People with higher levels of neuroticism have an increased risk of several types of mental disorder. Higher neuroticism has also been associated, less consistently, with increased risk of various physical health outcomes. We hypothesised that these associations may, in part, be due to shared genetic influences. We tested for pleiotropy between neuroticism and 17 mental and physical diseases or health traits using linkage disequilibrium regression and polygenic profile scoring. Genetic… CONTINUE READING
Highly Cited
This paper has 23 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 51 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Genetic contributions to self-reported tiredness

Molecular Psychiatry • 2018
View 2 Excerpts

Genetics of biologically based psychological differences

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2018